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essential thrombocythemia 2

C825T polymorphism 1

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expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essentialthrombocythemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 403-415 doi: 10.1007/s11684-021-0858-1

Abstract: developed MPN phenotype in myelofibrosis (MF) and secondary AML (sAML) transformed from MPNs versus essentialthrombocythemia (ET).

Keywords： myeloproliferative neoplasms     IRF4     IRF8     hydroxyurea     essential thrombocythemia    

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Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essentialthrombocythemia myelofibrosis in the Chinese population

Xin Du,Daobin Zhou

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 437-443 doi: 10.1007/s11684-016-0472-9

Abstract:

A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n=25) or 20 mg (n=38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.

Keywords： JAK     ruxolitinib     Chinese patients     myelofibrosis    

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Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essentialthrombocythemia

LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 309-313 doi: 10.1007/s11684-008-0059-1

Abstract: assays were developed and performed for JAK2V617F detection on 40 polycythemia vera (PV) samples, 31 essentialthrombocythemia (ET) samples, 40 acute leukemia samples, and 40 healthy control samples.

Keywords： specific amplification     essential thrombocythemia     Single-tube bi-directional     JAK2V617F-positive     JAK2V617F    

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Overlap maximum matching ratio (OMMR): a new measure to evaluate overlaps of essential modules

Xiao-xia ZHANG,Qiang-hua XIAO,Bin LI,Sai HU,Hui-jun XIONG,Bi-hai ZHAO

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4,   Pages 293-300 doi: 10.1631/FITEE.1400282

Abstract: Research shows that overlapping complexes can contribute to identifying essential proteins, which areComparison of essential proteins and gene ontology (GO) analysis are also used to assess the qualityindicate the important of overlaps and reveal the relationship between overlaps and identification of essential

Keywords： Protein-protein interaction network     Essential protein modules     Overlap     Overlap maximum matching ratio    

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A New Way to Study the Three Essential Factors of Forest Fire

Zhao Xianwen

Strategic Study of CAE 2000, Volume 2, Issue 5,   Pages 66-71

Abstract:

This thesis took the three essential factors of forest fire (fire source, environment, and litter)

Keywords： forecast of forest fire     space remote sensing     essential factors of forest fire     a new way    

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Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 230-233 doi: 10.1007/s11684-007-0045-z

Abstract: The relationship between the tenth exon C825T of G-protein β3 subunit (GNB) genetic polymorphism and hypertension in the Uygur population of China was investigated. A nested case-control study ( = 738) was carried out. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotype GNB C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects. The distributions of GNB C825T genotypes were CC (27.2%), TT (42.9%), and CT (29.9%) in the hypertensive subjects and CC (27.7%), TT (42.4%), CT (29.9%) in the normotensive subjects. There were no significant differences in the genotype distributions between the two groups ( = 0.0262 P = 0.99). The T allele was 51.4% in hypertensive subjects and 51.2% in normotensive subjects, which, between the two groups, was not a significant difference ( = 0.0016 P = 0.97). Further analysis shows that there is no association between C825T genotypes and age, body mass index (BMI), Glucose (GLU), Triglyceride (TG), Cholesterol (CHO), systolic blood pressure (SBP) and diastolic blood pressure (DBP). No evidence was found to suggest an association between GNB C825T polymorphism and hypertension in the Uygur population of China.

Keywords： case-control     significant difference     reaction-restriction fragment     C825T polymorphism     evidence    

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Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 227-235 doi: 10.1007/s11684-014-0327-1

Abstract:

Accelerated senescence is important because this process is involved in tumor suppression and has been induced by many chemotherapeutic agents. The platinum-based chemotherapeutic agent cisplatin displays a wide range of antitumor activities. However, the molecular mechanism of cisplatin-induced accelerated senescence in hepatocellular carcinoma (HCC) remains unclear. In the present study, the growth inhibitory effect of cisplatin on HepG2 and SMMC-7721 cells was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cellular senescence was then assessed by β-galactosidase assay. Senescence-related factors, including p53, p21, and p16, were evaluated by quantitative reverse transcription-polymerase chain reaction. Reactive oxygen species (ROS) was analyzed by flow cytometry. Our results revealed that cisplatin reduced the proliferation of HepG2 and SMMC-7721 cells in a dose- and time-dependent manner. Senescent phenotype observed in cisplatin-treated hepatoma cells was dependent on p53 and p21 activation but not on p16 activation. Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation. The ROS scavenger N-acetyl-L-cysteine also significantly suppressed the cisplatin-induced senescence of HepG2 and SMMC-7721 cells. In conclusion, our results revealed a functional link between intracellular ROS generation and cisplatin-induced accelerated senescence, and this link may be used as a potential target of HCC.

Keywords： reactive oxygen species     senescence     cisplatin     hepatocellular carcinoma    

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Cybersecurity Research—Essential to a Successful Digital Future

Jackie Craig

Engineering 2018, Volume 4, Issue 1,   Pages 9-10 doi: 10.1016/j.eng.2018.02.006

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Essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography

Yong G. Peng,Haibo Song,E. Wang,Weipeng Wang,Jin Liu

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 123-128 doi: 10.1007/s11684-014-0366-7

Abstract:

Guidelines for the intraoperative transesophageal echocardiography (TEE) examination have defined a detailed standard for medical professionals, particularly anesthesiologists, on how a TEE exam should proceed. Over the years, TEE has gained substantial popularity and emerged as a preferred monitoring modality to aid in perioperative management and decision making during hemodynamic instability situations or critical care settings. TEE training pathways and practice guidelines have been well established in western countries and many regions of the world. However, TEE training and practice information for anesthesiologists are lacking in China. As innovative technologies develop, other educational models have emerged to aid in obtaining competency in basic TEE exam. Hence, establishing a consensus on the ideal TEE training approach for anesthesiologists in China is urgently needed. Developing an effective curriculum that can be incorporated into an anesthesiology resident’s overall training is also necessary to provide knowledge and skills toward competency in basic TEE exam. With evolving medical system reforms and increasing demands for intraoperative hemodynamic monitoring to accommodate surgical innovations, anesthesiology professionals are increasingly obliged to perform intraoperative TEE exams in their current and future practices. To overcome obstacles and achieve significant progress in using the TEE modality to help in intraoperative management and surgical decision making, publishing basic TEE training guidelines for China’s anesthesiologists is an important endeavor.

Keywords： transesophageal echocardiography     guidelines     training     competency    

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Study on Harmony Mechanism of Virtual Enterprise

Wang Shuo,Tang Xiaowo

Strategic Study of CAE 2004, Volume 6, Issue 4,   Pages 82-85

Abstract:

In the paper, the operation and development essential factors and present harmony property analysis

Keywords： virtual enterprise     harmony mechanism     coordination     essential factor    

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is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice

Yuqin Men, Xiujuan Li, Hailong Tu, Aizhen Zhang, Xiaolong Fu, Zhishuo Wang, Yecheng Jin, Congzhe Hou, Tingting Zhang, Sen Zhang, Yichen Zhou, Boqin Li, Jianfeng Li, Xiaoyang Sun, Haibo Wang, Jiangang Gao

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 690-704 doi: 10.1007/s11684-018-0638-8

Abstract: encodes the taperin protein, which is concentrated in the tapered region of hair cell stereocilia in the inner ear. In humans, mutations cause autosomal recessive nonsyndromic deafness (DFNB79) by an unknown mechanism. To determine the role of in hearing, we generated -null mice by clustered regularly interspaced short palindromic repeat/Cas9 genome-editing technology from a CBA/CaJ background. We observed significant hearing loss and progressive degeneration of stereocilia in the outer hair cells of -null mice starting from postnatal day 30. Transmission electron microscopy images of stereociliary bundles in the mutant mice showed some stereociliary rootlets with curved shafts. The central cores of the stereociliary rootlets possessed hollow structures with surrounding loose peripheral dense rings. Radixin, a protein expressed at stereocilia tapering, was abnormally dispersed along the stereocilia shafts in null mice. The expression levels of radixin and -actin significantly decreased. We propose that is critical to the retention of the integrity of the stereociliary rootlet. Loss of in -null mice caused the disruption of the stereociliary rootlet, which resulted in damage to stereociliary bundles and hearing impairments. The generated -null mice are ideal models of human hereditary deafness DFNB79.

Keywords： TPRN     stereocilia     stereociliary rootlet     actin filament     CRISPR/Cas9     hearing    

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A Study on the Essence of Process Manufacturing

Fan Jiongming,Hu Shanying,Chen Dingjiang,Zhang Qun,Li Jin,Ma Shujie,,Song Xiaoxu,Jin Yong,Chen Bingzhen and Yin Ruiyu

Strategic Study of CAE 2017, Volume 19, Issue 3,   Pages 80-88 doi: 10.15302/J-SSCAE-2017.03.012

Abstract:

Process manufacturing is an important pillar of China's economic development, and its orderly and healthy development is of great significance to China’s economic and social development. However, the development of process manufacturing is constrained by its enormous consumption of resources and energy and its serious environmental impact. To reach a deeper understanding of the future development of process manufacturing, this study extends an analytical perspective from a single industry to all forms of process manufacturing. Based on the concepts of thermodynamics and entropy, this study analyzes the essence of process manufacturing. Three groups of key factors are used to build the analysis framework: flow and process; material, energy, and information; and scale and efficiency. A chemical engineering process and a phosphorus chemical process are then analyzed using this framework. The results show that the fundamental direction of the development of process manufacturing is to minimize the entropy increments of the whole system, rather than only those of the process system, while ignoring the entropy increments of the system of the external environment. In order to minimize the entropy increments of the whole system, it is necessary not only to pay attention to the economic benefits of the process system, but also to improve resource, energy, and environmental efficiency. To improve efficiency, the technology involved requires improvement, upgrading, and innovation. Improving and upgrading the technology can slightly improve the efficiency of a process system, while revolutionary innovation in the technology may greatly improve the efficiency.

Keywords： process manufacturing     entropy     process system     essence     essential characteristic    

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Putative Mode of Action of the Monoterpenoids Linalool, Methyl Eugenol, Estragole, and Citronellal on Ligand-Gated Ion Channels Article

Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen

Engineering 2020, Volume 6, Issue 5,   Pages 541-545 doi: 10.1016/j.eng.2019.07.027

Abstract:

Essential oil has been used as sedatives, anticonvulsants, and local anesthetics in traditional medicalcomponents such as methyl eugenol (ME), estragole (EG), and citronellal, are the active chemicals in many essentialConsidering that multiple monoterpenoids are found within the same essential oil, it is likely that LL

Keywords： Essential oil     γ-aminobutyric acid type A receptor     Linalool     Monoterpenoid     Nicotinic acetylcholine    

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A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China Article

Ting Zhang, Qing Wang, Zhiwei Leng, Yuan Yang, Jin Yang, Fangyuan Chen, Mengmeng Jia, Xingxing Zhang, Weiran Qi, Yunshao Xu, Siya Chen, Peixi Dai, Libing Ma, Luzhao Feng, Weizhong Yang

Engineering 2021, Volume 7, Issue 7,   Pages 948-957 doi: 10.1016/j.eng.2021.03.020

Abstract: This study aimed to assess COVID-19-related essential clinical resource demands in China, based on differentdynamics model to estimate the number of COVID-19 infections and hospitalizations with corresponding essentialIt also provides guidance for essential healthcare investment and resource allocation.

Keywords： COVID-19     Transmission dynamics model     Clinical resource demands     Vaccination    

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Title Author Date Type Operation

expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essentialthrombocythemia

Journal Article

Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essentialthrombocythemia myelofibrosis in the Chinese population

Xin Du,Daobin Zhou

Journal Article

Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essentialthrombocythemia

LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping

Journal Article

Overlap maximum matching ratio (OMMR): a new measure to evaluate overlaps of essential modules

Xiao-xia ZHANG,Qiang-hua XIAO,Bin LI,Sai HU,Hui-jun XIONG,Bi-hai ZHAO

Journal Article

A New Way to Study the Three Essential Factors of Forest Fire

Zhao Xianwen

Journal Article

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Journal Article

Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular

Kai Qu,Ting Lin,Zhixin Wang,Sinan Liu,Hulin Chang,Xinsen Xu,Fandi Meng,Lei Zhou,Jichao Wei,Minghui Tai,Yafeng Dong,Chang Liu

Journal Article

Cybersecurity Research—Essential to a Successful Digital Future

Jackie Craig

Journal Article

Essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography

Yong G. Peng,Haibo Song,E. Wang,Weipeng Wang,Jin Liu

Journal Article

Study on Harmony Mechanism of Virtual Enterprise

Wang Shuo,Tang Xiaowo

Journal Article

is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice

Yuqin Men, Xiujuan Li, Hailong Tu, Aizhen Zhang, Xiaolong Fu, Zhishuo Wang, Yecheng Jin, Congzhe Hou, Tingting Zhang, Sen Zhang, Yichen Zhou, Boqin Li, Jianfeng Li, Xiaoyang Sun, Haibo Wang, Jiangang Gao

Journal Article

A Study on the Essence of Process Manufacturing

Fan Jiongming,Hu Shanying,Chen Dingjiang,Zhang Qun,Li Jin,Ma Shujie,,Song Xiaoxu,Jin Yong,Chen Bingzhen and Yin Ruiyu

Journal Article

Putative Mode of Action of the Monoterpenoids Linalool, Methyl Eugenol, Estragole, and Citronellal on Ligand-Gated Ion Channels

Amy S. Li, Akimasa Iijima, Junhao Huang, Qing X. Li, Yongli Chen

Journal Article

A Scenario-Based Evaluation of COVID-19-Related Essential Clinical Resource Demands in China

Ting Zhang, Qing Wang, Zhiwei Leng, Yuan Yang, Jin Yang, Fangyuan Chen, Mengmeng Jia, Xingxing Zhang, Weiran Qi, Yunshao Xu, Siya Chen, Peixi Dai, Libing Ma, Luzhao Feng, Weizhong Yang

Journal Article